MICROCURRENT ACUPUNCTURE AND THIAMINE THERAPY (MATT)
FOR PARKINSON’S DISEASE

MATT Therapy Overview

Microcurrent Acupuncture & Thiamine Therapy for Parkinson’s Disease

(MATT) Microcurrent Acupuncture and Thiamine Therapy is an integrative therapy that can be used either as a stand-alone approach or as a complementary therapy alongside conventional medical treatments for Parkinson’s disease.

Clinical observations suggest that MATT may help improve both motor and non-motor symptoms, including:

  • Fatigue

  • Tremor

  • Mood disturbances

  • Sleep quality

  • Speech and handwriting performance

MATT may also benefit certain neurodegenerative, immune-related, and inflammatory conditions by enhancing cellular energy and supporting neurological function.

MATT is designed to work safely alongside standard medical treatments (such as Levodopa and other neurological therapies) with the goals of:

  • Enhancing treatment outcomes

  • Reducing side effects

  • Improving daily function and quality of life

What is Microcurrent Acupuncture (MA)?

Microcurrent Acupuncture (MA) combines internationally standardized scalp acupuncture with frequency-specific microcurrent stimulation to regulate neurological function.

Treatment Method

  • Based on functional scalp zones (motor area, sensory area, tremor control area, etc.)

  • Typically 2–4 sterile acupuncture needles are used

  • Combined with specific microcurrent frequencies

  • Each session lasts approximately 15–30 minutes

  • Treatment frequency is adjusted according to disease severity and response

Observed Clinical Effects

Many patients experience immediate improvements even after the first session, including:

  • Reduced tremor amplitude

  • Easier movement initiation

  • Clearer speech

  • More stable walking

  • Improved mood and sleep

Therapeutic effects may last 1–3 weeks or longer, depending on disease duration and neurological damage.

Microcurrent Acupuncture is a safe, non-invasive, and painless therapy, and the technique is also highly teachable to both Chinese and Western registered acupuncturists.

How does Microcurrent acupuncture(MA)?

How does microcurrent acupuncture work?
The endogenous electrical signals were discovered many years ago. Using modern techniques, the existence of these natural electrical fields has now been well established.  These natural electrical signals play a pivotal role in many fundamental processes, one notably being in wound healing. By apply selected microcurrents which mimic these signals, healing can be enhanced for healing of brain cells.

Secondly, microcurrent stimulation is also known to provide a direct energy-related benefit to the mitochondria* within the cells, which are responsible for producing around 90% of cellular energy. The applied currents provide a means of an additional resource, which can be directly used in the production of ATP* (Adenosine Triphosphate). More ATP means faster cell repair and regeneration, which is why microcurrent therapy enhance recovering and reduce fatigue.

In its simplest form, microcurrent is able to facilitate naturally occurring electrical processes that are essential to the wellbeing of our nerve cells, by increasing blood flow blood circulation, which can help deliver oxygen and nutrients to the brain cells, potentially reducing inflammation and promoting healing. This means that regardless of the type damage or condition, virtually certain every Parkinson’s patient can gain notable benefits and improvements from using this technology, which is truly remarkable!

What is ATP* and Mitochondria* ?

ATP* (Adenosine Triphosphate) is the main energy source for cells, often called the "energy currency" of the body. It provides power for essential processes like muscle movement, nerve signaling, tissue repair, and metabolism.

Mitochondria* are like tiny power plants inside our cells. They make energy (called ATP) so the cells can work properly. Besides making energy, mitochondria also
1. Help control when a cell should die (apoptosis)
2. Store calcium
3. Support the immune system
4. Producing reactive oxygen species (ROS) that act like signals (but too much can be harmful)
They even have their own DNA, which shows they might have evolved from ancient bacteria.

ATP is primarily produced by the mitochondria, which generate energy by breaking down nutrients. More ATP means faster cell repair and regeneration, which is why microcurrent therapy help enhance healing and reduce fatigue.

What is Thiamine Therapy(TT)?

Thiamine and Vitamin B1 are exactly the same substance. “Thiamine” is the scientific chemical name, while “Vitamin B1” is the common nutritional name.

Thiamine Therapy was developed by Dr. Antonio Costantini (Italy) using high-dose Vitamin B1 (Thiamine). This approach has already helped thousands of Parkinson’s patients worldwide.

Dosage Adjustment Principles (Oral Thiamine HCL)

Dosage is individually adjusted based on:

  • Duration of disease

  • Severity of symptoms

  • Body weight

  • Individual treatment sensitivity

Typical clinical oral dosage range:
100mg per day
Always consult a doctor before using high doses.

Dr. Antonio Costantini oral doses goes up to 2-4 gram. He also used B1 injection.

Thiamine HCL is recommended. Thiamine Mononitrate is not recommended for long-term high-dose use due to potential kidney stone risk.

B-Complex does NOT replace high-dose Thiamine therapy. B-Complex is for basic nutritional support.
High-dose Thiamine is a targeted metabolic therapy for neurological conditions.
One cannot replace the other.

Mechanism of Thiamine Therapy (TT)?

Mechanism of Thiamine Therapy

Research suggests that even when blood B1 levels appear normal, Parkinson’s patients may suffer from functional intracellular thiamine deficiency, leading to:

  • Impaired mitochondrial energy metabolism

  • Reduced dopamine synthesis

  • Increased oxidative stress

  • Progressive neuronal damage

High-dose thiamine may help:

  • Restore mitochondrial function

  • Increase ATP energy production

  • Support dopaminergic neuron activity

  • Reduce long-term neurodegeneration

Clinical observations show:

  • Significant symptom improvement

  • Potential slowing or temporary stabilization of disease progression

MATT Therapy Summary

Why Combine MA + TT (MATT)?

The core advantage of MATT is the strategic combination of immediate neurological regulation + long-term metabolic support:

🔹 Microcurrent Acupuncture (MA)

  • Provides rapid neuromodulation

  • Quickly improves tremor, mobility, mood, and sleep

  • Directly stimulates ATP production and neuronal energy availability

🔹 Thiamine Therapy (TT)

  • Repairs energy metabolism at the cellular and mitochondrial level

  • Provides mid- to long-term neuroprotection

  • Supports dopamine system function

✅ Combined Benefits of MATT

  • Early stage: MA delivers fast symptom relief

  • Mid-to-long term: TT stabilizes neurological function

  • Once TT dosage stabilizes and symptoms improve, the frequency of MA sessions can often be gradually reduced

  • MA therapy can reduce the required dosage of Vitamin B1, while Vitamin B1 therapy can, in turn, reduce the number of MA treatment sessions needed. Together, they demonstrate a strong synergistic effect

Clinical Experience & Evidence

Kinman Clinic (HK & UK)

  • Applied Microcurrent Acupuncture for chronic pain over 10 years ago

  • Later extended to Parkinson’s disease and other neurodegenerative conditions

  • Accumulated many encouraging clinical case outcomes


Dr. Antonio Costantini (Italy)

  • Developed High-Dose Thiamine Therapy for Parkinson’s disease

  • Has helped thousands of patients worldwide

  • Clinical reports show significant improvements in both motor and non-motor symptoms


Although these two systems act through different mechanisms, their combined use demonstrates strong clinical complementarity and therapeutic synergy.


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Important Medical Disclaimer

MATT is a complementary therapy. While clinical observations indicate that MATT may significantly reduce symptoms and potentially slow disease progression in some patients, larger-scale clinical trials are still required for full scientific validation.
MATT does not replace conventional medical diagnosis or treatment.

Parkinson’s disease

What is Parkinson’s Disease?
Parkinson’s is a progressive neurological condition that affects the brain. It develops when nerve cells in a specific area of the brain become damaged and die over time. These cells produce a vital chemical called dopamine, which helps send messages in the brain to control movement—everything from walking and speaking, to writing and smiling.

As more dopamine-producing cells are lost, the brain can't make enough dopamine to manage movement properly. That’s when symptoms begin. Early signs can be subtle, like smaller handwriting, but as the condition progresses, movement difficulties become more pronounced. Common symptoms include:

Motor symptoms:

  • Muscle stiffness

  • Slowness of movement

  • Tremors or shaking

  • Falls or balance issues

  • Resting tremor

  • Rigidity

  • Freezing episodes (sudden inability to move)

  • Restless Legs Syndrome

  • Speech difficulties

  • Problems with swallowing

Non-motor symptoms:

  • Fatigue

  • Memory problems

  • Bladder issues

  • Pain

  • Anxiety

  • Bowel problems (e.g. constipation)

  • Sleep disturbances

  • Dizziness

  • Hallucinations


Can Parkinson’s be cure?
Scientists still don’t fully understand why dopamine-producing cells die in some people or what exactly causes Parkinson’s disease. However, researchers around the world are working hard to uncover the reasons, protect the remaining cells, and develop better treatments—with the ultimate goal of finding a cure. Clinical observations suggest that Microcurrent Acupuncture and Thiamine Therapy (MATT) may significantly slow disease progression and markedly reduce symptoms in some patients. However, larger and controlled studies are still needed to confirm its long-term effects.

Scalp acupuncture

What is Scalp acupuncture?
Scalp acupuncture, also known as Chinese scalp needling therapy, is a specialized form of acupuncture that integrates traditional Chinese meridian theory with modern brain anatomy. Fine needles are inserted into specific scalp zones that correspond to functional areas of the brain—such as motor, sensory, and speech regions—to stimulate neurological recovery and enhance brain function. This technique is widely used in stroke rehabilitation and in the treatment of neurological conditions such as Parkinson’s disease, dementia, paralysis, and speech disorders.

Immediate effect with Microcurrent Scalp Acupuncture
Scalp acupuncture combined with microcurrent therapy is highly effective for patients with Parkinson’s disease. In most cases, noticeable improvements can be seen during the first treatment - motor symptoms such as tremors are reduced by more than half, and non-motor symptoms like fatigue, moody and voice issues also show improvement. Clinical evidence indicate that the therapeutic effects of this treatment can last for a relatively long period.

Three Images show:
1. Scalp acupuncture point localization
2. Anatomical localization
3. Scalp Acupuncture with microcurrent with specific frequency enhancing the effectiveness

“Microamp stimulation has also been called ‘biostimulation’ to ‘bioelectric therapy’ because of its ability to stimulate cellular physiology and growth.”

- Robert Picker, M.D., wrote -

Thiamine Therapy (Oral tablets)

What is Thiamine Therapy (TT)?
Dr. Antonio Costantini and his team developed a High-Dose Thiamine (vitamin B1) therapy to help relieve symptoms of Parkinson’s disease and various other neurodegenerative and autoimmune conditions. His Thiamine therapy has already helped thousands of People with Parkinson’s disease. Through clinical observation, they reported significant improvements in patients suffering from:

  • Parkinson’s disease

  • Essential tremor

  • Fibromyalgia

  • Spinocerebellar ataxia type 2

  • Huntington’s disease

  • Cluster headaches

  • Migraine

  • and many other neurological and immune-related disorders.

This therapy stands out for being simple, safe, and cost-effective, offering hope to patients with chronic and complex conditions. The high-dose thiamine (HDT) protocol can be a helpful addition to standard treatments, improving results and reducing side effects.

How does Thiamine Therapy work?
Parkinson’s disease leads to the death of neurons through its interaction with the intracellular metabolism of thiamine. This action can be blocked by the administration of high doses of thiamine. The neurons, once no longer burdened by the primary cause of the disease, restart their activity and this leads to the improvement of most symptoms.

Continuing the therapy, the neurons might stay healthy regardless of the existence of PD. Thus, in addition to a rapid improvement of the symptoms we observe also a freezing of the evolution of the disease.

However, the primary cause of the disease is not directly interested by the therapy. High dose thiamine does not eliminate the primary cause of the disease but blocks all damages inflicted by the disease. Therefore, the high dose thiamine is a pathogenetic therapy. The therapy thus limits the degeneration of the nervous system which continues to work efficiently when freed from the limitations posed by the disease.


Effect of Suspending Thiamine Treatment
When the high dose thiamine is suspended after a cycle of treatments of three months, the beneficial effects do not cease right away but start to diminish within the next two months. We believe that this happens because the mechanisms of action of the disease have a certain buffer effect which in turn requires a couple of months before getting back to the status of the symptoms before the use of high dose thiamine.

Side effect
Because thiamine HCL is a water-soluble vitamin with renal clearance, the risk of thiamine accumulation is limited for patients with normal kidney function.

Dr Costantini recommended using B1 hydrochloride (HCL) not B1 mononitrate. Both are synthetic, but thiamine HCL is more water soluble and therefore is not likely to build up in the body. Thought low levels of thiamine mononitrate are unlikely to cause any severe problems, but high dose of thiamine mononitrate molecules may accumulate in the kidneys and induce kidney stones when taken in high doses.

Summary of Thiamine Therapy

Mechanisms
Thiamine plays a vital role in numerous cellular functions, including energy metabolism, dopamine synthesis, and the maintenance of mitochondrial integrity. A deficiency in thiamine can disrupt these processes, leading to oxidative stress, mitochondrial dysfunction, and impaired dopamine production — all of which are implicated to the pathogenesis of Parkinson’s disease.

Clinical Evidence
Clinical studies show that thiamine may help treat Parkinson’s disease. A 2019 study in the Journal of Parkinson’s Disease found that thiamine supplements improved motor symptoms such as stiffness, walking, and hand movement. High-dose thiamine has been tested for its effect on movement in Parkinson’s patients. Research also shows that people with Parkinson’s often have lower levels of thiamine and its active forms in their spinal fluid and blood compared to healthy people.

Benefits
Thiamine supplementation can enhance cellular energy production and reduce oxidative stress, which may indirectly help alleviate motor symptoms in Parkinson’s disease. Thiamine’s critical role in dopamine synthesis, its supplementation might also directly address dopamine deficiency — a core feature of the disease. Furthermore, thiamine’s neuroprotective effects on mitochondrial function could contribute to slowing disease progression by preserving overall cellular health.

Dosage
The optimal oral dosage of thiamine for PD patients remains under investigation, with dosages used in ranging from 100mg to 3000mg per day. Factors such as disease severity, individual variability, and comorbidities should be considered when determining dosage.

Combination Therapies
Comibining thiamine therapy with other interventions, such as Microcurrent Scalp Acupuncture, dopamine replacement therapy, antioxidants, mitochondrial support, exercise, and anti-inflammatory agents, may provide a holistic approach to PD management. The potential benefits of combination therapies include synergistic effects, improved symptom control, and potentially slowing disease progression.

Considerations and Challenges
Safety, interactions, and individual variability should be carefully considered when implementing B1 therapy, alone or in combination with other intervention treatments. Long-term observation are need to assess the sustained effects and safety of thiamine supplementation.