PARKINSON’S & DEMENTIA CLINIC GROUP

MICROCURRENT ACUPUNCTURE AND THIAMINE THERAPY (MATT)
FOR PARKINSON’S DISEASE

MATT Therapy for Parkinson’s disease

MATT Therapy Summary

Microcurrent Acupuncture and Thiamine Therapy (MATT)
Microcurrent Acupuncture and Thiamine Therapy (MATT) is a combined or stand-alone therapy for someone with Parkinson’s disease. It can help improve symptoms such as fatigue, tremor, moody disturbances and other more. MATT may also benefit people with other neurodegenerative, autoimmune related, or inflammatory conditions by reducing fatigue and improving a wide range of symptoms. MATT therapy can be a valuable addition to standard treatments, potentially enhancing outcomes and reducing side effects.

Microcurrent Acupuncture (MA)
- According to international scalp acupuncture standards, approximately 3 to 6 sterile needles are applied to specific scalp areas with microcurrent using a set frequency, each session lasting 15 to 30 minutes.;
- The frequency of session per month depends on the severity of the symptoms;
- Immediate results in reducing symptoms such as tremor, speech as well as the non-motor symptoms after the first session;
- Improvement sustains for 1 to 3 weeks or even longer depends on the duration and the severity of the disease.

Thiamine Therapy (TT)
Find the correct B1 Thiamine dose according to:
- Duration of the disease (The longer someone has the disease, the more B1 thiamine);
- Severity of the symptoms;
- Weight of the patient;
- Sensitivity to the treatment;
- B1 thiamine dose from 2 to 4 grams/day.

Combinating of these two therapies provides substantial benefits for patients.

The Microcurrent Acupuncture (MA) component provides immediate effects on motor symptoms such as reducing tremors, as well as other non-motor symptoms such as improve mood. This acupuncture technique is easy to learn for all registered Chinese and Western acupuncture practitioners. Most of the symptoms can improve instantly when paired with the appropriate microcurrent frequencies.

As for Thiamine Therapy (TT), it involves a process of trial and error to determine the optimal dosage, which may take time. However, once the correct dosage is established and symptoms improve, the frequency of microcurrent Acupuncture treatment can be reduced accordingly.

Creating Before-Treatment Videos
Before starting therapy, it is recommended that the patient records a video of him/herself as a baseline. The video should include:

  • Facial expressions

  • Tremors

  • Speech

  • Walking gait

  • A pull test to assess balance and postural stability

This initial recording serves as a reference point. During the course of therapy, similar videos should be taken at regular intervals to allow for comparison. This visual documentation helps track subtle or significant improvements over time and provides valuable information for both the patient and the healthcare team in evaluating treatment progress.

MATT Clinical Evidence

Clinical Evidence
Kinman’s and Dr. Costantini’s YouTube channels present clear clinical improvements observed during and after treatment. Over 10 years ago, Kinman Clinic pioneered the use of Microcurrent Acupuncture (MA) Therapy in Hong Kong, initially focusing on patients with chronic pain. Later, this MA therapy was extended to patients with neurodegenerative conditions such as Parkinson’s disease, yielding promising and satisfactory clinical outcomes.

Meanwhile, in Italy, Dr. Antonio Costantini developed High Dose Thiamine vitamin-B1 (TT) therapy to relieve symptoms of Parkinson’s disease as well as various other neurodegenerative and autoimmune disorders. His approach has already helped thousands of patients with Parkinson’s disease experience significant clinical improvements.

Though based on different mechanisms, combination treatment approaches show strong potential in supporting patients with neurological conditions and warrant further clinical investigation and broader application.

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Parkinson’s disease

What is Parkinson’s Disease?
Parkinson’s is a progressive neurological condition that affects the brain. It develops when nerve cells in a specific area of the brain become damaged and die over time. These cells produce a vital chemical called dopamine, which helps send messages in the brain to control movement—everything from walking and speaking, to writing and smiling.

As more dopamine-producing cells are lost, the brain can't make enough dopamine to manage movement properly. That’s when symptoms begin. Early signs can be subtle, like smaller handwriting, but as the condition progresses, movement difficulties become more pronounced. Common symptoms include:

Motor symptoms:

  • Muscle stiffness

  • Slowness of movement

  • Tremors or shaking

  • Falls or balance issues

  • Resting tremor

  • Rigidity

  • Freezing episodes (sudden inability to move)

  • Restless Legs Syndrome

  • Speech difficulties

  • Problems with swallowing

Non-motor symptoms:

  • Fatigue

  • Memory problems

  • Bladder issues

  • Pain

  • Anxiety

  • Bowel problems (e.g. constipation)

  • Sleep disturbances

  • Dizziness

  • Hallucinations


Can Parkinson’s be cure?
Scientists still don’t fully understand why dopamine-producing cells die in some people or what exactly causes Parkinson’s disease. However, researchers around the world are working hard to uncover the reasons, protect the remaining cells, and develop better treatments—with the ultimate goal of finding a cure. Microcurrent Acupuncture and Thiamine Therapy (MATT) can halt disease progression and eliminate symptoms.

Microcurrent acupuncture

How does microcurrent acupuncture work?
The endogenous electrical signals were discovered many years ago. Using modern techniques, the existence of these natural electrical fields has now been well established.  These natural electrical signals play a pivotal role in many fundamental processes, one notably being in wound healing. By apply selected microcurrents which mimic these signals, healing can be enhanced for healing of brain cells.

Secondly, microcurrent stimulation is also known to provide a direct energy-related benefit to the mitochondria* within the cells, which are responsible for producing around 90% of cellular energy. The applied currents provide a means of an additional resource, which can be directly used in the production of ATP* (Adenosine Triphosphate). More ATP means faster cell repair and regeneration, which is why microcurrent therapy enhance recovering and reduce fatigue.

In its simplest form, microcurrent is able to facilitate naturally occurring electrical processes that are essential to the wellbeing of our nerve cells, by increasing blood flow blood circulation, which can help deliver oxygen and nutrients to the brain cells, potentially reducing inflammation and promoting healing. This means that regardless of the type damage or condition, virtually certain every Parkinson’s patient can gain notable benefits and improvements from using this technology, which is truly remarkable!

ATP* and Mitochondria*

ATP* (Adenosine Triphosphate) is the main energy source for cells, often called the "energy currency" of the body. It provides power for essential processes like muscle movement, nerve signaling, tissue repair, and metabolism.

Mitochondria* are like tiny power plants inside our cells. They make energy (called ATP) so the cells can work properly. Besides making energy, mitochondria also
1. Help control when a cell should die (apoptosis)
2. Store calcium
3. Support the immune system
4. Producing reactive oxygen species (ROS) that act like signals (but too much can be harmful)
They even have their own DNA, which shows they might have evolved from ancient bacteria.

ATP is primarily produced by the mitochondria, which generate energy by breaking down nutrients. More ATP means faster cell repair and regeneration, which is why microcurrent therapy help enhance healing and reduce fatigue.

Scalp acupuncture

What is Scalp acupuncture?
Scalp acupuncture, also known as Chinese scalp needling therapy, is a specialized form of acupuncture that integrates traditional Chinese meridian theory with modern brain anatomy. Fine needles are inserted into specific scalp zones that correspond to functional areas of the brain—such as motor, sensory, and speech regions—to stimulate neurological recovery and enhance brain function. This technique is widely used in stroke rehabilitation and in the treatment of neurological conditions such as Parkinson’s disease, dementia, paralysis, and speech disorders.

Immediate effect with Microcurrent Scalp Acupuncture
Scalp acupuncture combined with microcurrent therapy is highly effective for patients with Parkinson’s disease. In most cases, noticeable improvements can be seen during the first treatment - motor symptoms such as tremors are reduced by more than half, and non-motor symptoms like fatigue, moody and voice issues also show improvement. Clinical evidence indicate that the therapeutic effects of this treatment can last for a relatively long period.

Three Images show:
1. Scalp acupuncture point localization
2. Anatomical localization
3. Scalp Acupuncture with microcurrent with specific frequency enhancing the effectiveness

“Microamp stimulation has also been called ‘biostimulation’ to ‘bioelectric therapy’ because of its ability to stimulate cellular physiology and growth.”

- Robert Picker, M.D., wrote -

Thiamine Therapy

What is Thiamine Therapy (TT)?
Dr. Antonio Costantini and his team developed a High-Dose Thiamine (vitamin B1) therapy to help relieve symptoms of Parkinson’s disease and various other neurodegenerative and autoimmune conditions. His Thiamine therapy has already helped thousands of People with Parkinson’s disease. Through clinical observation, they reported significant improvements in patients suffering from:

  • Parkinson’s disease

  • Essential tremor

  • Fibromyalgia

  • Spinocerebellar ataxia type 2

  • Huntington’s disease

  • Cluster headaches

  • Migraine

  • and many other neurological and immune-related disorders.

This therapy stands out for being simple, safe, and cost-effective, offering hope to patients with chronic and complex conditions. The high-dose thiamine (HDT) protocol can be a helpful addition to standard treatments, improving results and reducing side effects.

How does Thiamine Therapy work?
Parkinson’s disease leads to the death of neurons through its interaction with the intracellular metabolism of thiamine. This action can be blocked by the administration of high doses of thiamine. The neurons, once no longer burdened by the primary cause of the disease, restart their activity and this leads to the improvement of most symptoms.

Continuing the therapy, the neurons might stay healthy regardless of the existence of PD. Thus, in addition to a rapid improvement of the symptoms we observe also a freezing of the evolution of the disease.

However, the primary cause of the disease is not directly interested by the therapy. High dose thiamine does not eliminate the primary cause of the disease but blocks all damages inflicted by the disease. Therefore, the high dose thiamine is a pathogenetic therapy. The therapy thus limits the degeneration of the nervous system which continues to work efficiently when freed from the limitations posed by the disease.


Effect of Suspending Thiamine Treatment
When the high dose thiamine is suspended after a cycle of treatments of three months, the beneficial effects do not cease right away but start to diminish within the next two months. We believe that this happens because the mechanisms of action of the disease have a certain buffer effect which in turn requires a couple of months before getting back to the status of the symptoms before the use of high dose thiamine.

Summary of Thiamine Therapy

Mechanisms
Thiamine plays a vital role in numerous cellular functions, including energy metabolism, dopamine synthesis, and the maintenance of mitochondrial integrity. A deficiency in thiamine can disrupt these processes, leading to oxidative stress, mitochondrial dysfunction, and impaired dopamine production — all of which are implicated to the pathogenesis of Parkinson’s disease.

Clinical Evidence
Clinical studies show that thiamine may help treat Parkinson’s disease. A 2019 study in the Journal of Parkinson’s Disease found that thiamine supplements improved motor symptoms such as stiffness, walking, and hand movement. High-dose thiamine has been tested for its effect on movement in Parkinson’s patients. Research also shows that people with Parkinson’s often have lower levels of thiamine and its active forms in their spinal fluid and blood compared to healthy people.

Benefits
Thiamine supplementation can enhance cellular energy production and reduce oxidative stress, which may indirectly help alleviate motor symptoms in Parkinson’s disease. Thiamine’s critical role in dopamine synthesis, its supplementation might also directly address dopamine deficiency — a core feature of the disease. Furthermore, thiamine’s neuroprotective effects on mitochondrial function could contribute to slowing disease progression by preserving overall cellular health.

Dosage
The optimal oral dosage of thiamine for PD patients remains under investigation, with dosages used in ranging from 100mg to 3000mg per day. Factors such as disease severity, individual variability, and comorbidities should be considered when determining dosage.

Combination Therapies
Comibining thiamine therapy with other interventions, such as Microcurrent Scalp Acupuncture, dopamine replacement therapy, antioxidants, mitochondrial support, exercise, and anti-inflammatory agents, may provide a holistic approach to PD management. The potential benefits of combination therapies include synergistic effects, improved symptom control, and potentially slowing disease progression.

Considerations and Challenges
Safety, interactions, and individual variability should be carefully considered when implementing B1 therapy, alone or in combination with other intervention treatments. Long-term observation are need to assess the sustained effects and safety of thiamine supplementation.